Rethinking the Regulation of L-Carnitine Transport in Skeletal Muscle Cells. Focus on "the Role of AMPK"
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چکیده
Rethinking the Regulation of L-Carnitine Transport in Skeletal Muscle Cells. 1 Focus on “the Role of AMPK” 2 3 4 Da Xu and Guofeng You* 5 6 Department of Pharmaceutics, Rutgers University, Piscataway, NJ, USA 08854 7 8 9 Running Title: The Role of AMPK in the Regulation of L-Carnitine Transport 10 11 12 13 *Corresponding Author: 14 Guofeng You, Ph.D. 15 Dept. of Pharmaceutics, 16 Rutgers, the State University of New Jersey, 17 160 Frelinghuysen Road, Piscataway, NJ 08854, 18 Tel: 848-445-6349 19 E-mail: [email protected] 20 21 Articles in PresS. Am J Physiol Cell Physiol (April 19, 2017). doi:10.1152/ajpcell.00093.2017
منابع مشابه
Rethinking the regulation of l-carnitine transport in skeletal muscle cells. Focus on "Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes".
CARNITINE IS A CRITICAL COFACTOR in the metabolism of lipids and therefore in the production of cellular energy. L-Carnitine, the active form, plays an important role in oxidizing fatty acids, transporting long chain fatty acids across mitochondrial membrane, and modulating intracellular coenzyme A homeostasis (3). L-Carnitine uptake into cells is mediated primarily by the organic cation/carnit...
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Introduction: AMP activated protein kinase (AMPK) as key regulators of cell metabolism, plays a major role in the activation of catabolic pathways, such as glucose transport and fatty acid oxidation. Thus, activation of this pathway can be used in the treatment of diabetes and metabolic syndrome. Many studied proposed the effectiveness of the polyphenols present in rhizomes of turmeric (curcumi...
متن کاملMultiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes.
Mutations in the gene that encodes the principal l-carnitine transporter, OCTN2, can lead to a reduced intracellular l-carnitine pool and the disease Primary Carnitine Deficiency. l-Carnitine supplementation is used therapeutically to increase intracellular l-carnitine. As AMPK and insulin regulate fat metabolism and substrate uptake, we hypothesized that AMPK-activating compounds and insulin w...
متن کاملSkeletal muscle lipid metabolism in exercise and insulin resistance.
Lipids as fuel for energy provision originate from different sources: albumin-bound long-chain fatty acids (LCFA) in the blood plasma, circulating very-low-density lipoproteins-triacylglycerols (VLDL-TG), fatty acids from triacylglycerol located in the muscle cell (IMTG), and possibly fatty acids liberated from adipose tissue adhering to the muscle cells. The regulation of utilization of the di...
متن کاملStructural changes of cardiac tissue in response to L-carnitine supplementation during endurance training in Wistar male rats toxicated by steroid anabolic hormone
Introduction: The aim of this study was to investigate the structural changes of cardiac tissue in response to L-carnitine supplementation and endurance training in Wistar male rats toxicated by steroid anabolic hormone. Methods: 36 male Wistar rats aged 8-12 weeks (weight 195±7.94g) were randomly divided into six groups: Control, Non-treated, Boldenone (5 mg/kg), L-carnitine (100 mg pe...
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تاریخ انتشار 2017